Struggling to choose between SkinMedica and Alastin for radiant skin?
I’ve tested both and I’m spilling my experience to help you decide!
This article compares their key products, pros, cons, and features, with a handy table and FAQs.
Whether you’re fighting wrinkles or hyperpigmentation, I’ll guide you to the brand that suits your glow-up goals!
Comparison Table: SkinMedica Vs. Alastin
Feature/Product | SkinMedica | Alastin |
Hero Product | TNS Advanced+ Serum ($295, 1 oz) | Restorative Skin Complex ($199, 1 oz) |
Key Technology | TNS-MR growth factors, peptides | TriHex Technology® peptides |
Main Focus | Anti-aging, hyperpigmentation, hydration | Anti-aging, post-procedure recovery, firmness |
Price Range | $40-$295 | $50-$199 |
Star Ingredients | Growth factors, hyaluronic acid, niacinamide | Peptides, hyaluronic acid, antioxidants |
Best For | Fine lines, uneven tone, sensitive skin | Post-procedure, sagging skin, elasticity |
Availability | Authorized retailers (Dermstore, LovelySkin) | Derm offices, Alastin.com |
Medical Grade | Yes | Yes |
Clinical Studies | Extensive (e.g., 83% even tone for Even & Correct) | 60+ peer-reviewed studies |
My Journey with SkinMedica and Alastin

I’m a 42-year-old freelance writer in Austin, juggling deadlines and a skincare obsession.
Fine lines around my eyes and sunspots from Texas summers pushed me to try medical-grade brands.
SkinMedica and Alastin, both derm-loved, caught my eye.
I tested SkinMedica’s TNS Advanced+ Serum ($295, 1 oz) and Even & Correct Advanced Brightening Treatment ($178, 2 oz), then Alastin’s Restorative Skin Complex ($199, 1 oz) and A-Luminate Brightening Serum ($178, 1.7 oz) over six months.
Here’s how it went.
SkinMedica’s TNS Advanced+ Serum felt like a luxe treat.
Its dual-chamber pump (growth factors on one side, peptides on the other) glided on smoothly, with a faint herbal scent.
After two weeks, my crow’s feet softened, and my skin looked plumper.
By month two, my forehead lines were less noticeable—friends thought I’d gotten Botox!
The Even & Correct serum tackled my sunspots.
Its creamy texture absorbed fast, and by week six, my cheeks were visibly brighter.
No irritation, even on my sensitive skin, but the price stung.
Alastin’s Restorative Skin Complex was a game-changer post-microneedling.
Its silky feel, thanks to TriHex Technology®, soothed my red face overnight.
After a month, my skin felt firmer, like it had a new bounce.
The A-Luminate Brightening Serum targeted my hyperpigmentation with niacinamide and peptides.
It faded dark spots on my jawline by week four, though results were slower than SkinMedica’s.
Alastin’s lightweight formulas layered well under sunscreen, but I needed extra moisturizer in winter.
Both brands impressed, but SkinMedica edged out for daily anti-aging, while Alastin shined for recovery and firmness.
Your skin’s needs will tip the scale—let’s break it down further.
About SkinMedica
Founded in 1999 by Dr. Richard Fitzpatrick, SkinMedica is a medical-grade brand under AbbVie, based in California.
Its TNS (Tissue Nutrient Solution) growth factor technology, paired with peptides and hyaluronic acid, targets wrinkles, sagging, and uneven tone.
Products like HA5 Rejuvenating Hydrator and Even & Correct are sold through authorized retailers like Dermstore.
Clinical studies, like 83% of users seeing even tone with Even & Correct, back its claims.
About Alastin
Launched in 2015 by plastic surgeon Dr. Alan Widgerow, Alastin focuses on anti-aging and post-procedure care.
Its TriHex Technology®, a peptide blend, clears damaged collagen to boost new elastin production.
Products like Regenerating Skin Nectar and Restorative Skin Complex are derm-endorsed, with over 60 peer-reviewed studies.
Available at dermatologist offices and Alastin.com, it’s a go-to for procedure prep and recovery.
Pros of SkinMedica:

- Visible Anti-Aging: TNS Advanced+ softens fine lines fast. My crow’s feet faded in weeks.
- Brightens Tone: Even & Correct evens complexion. My sunspots lightened dramatically.
- Hydrating: HA5 locks in moisture. My dry patches vanished overnight.
- Non-Irritating: Gentle for sensitive skin. No redness, even with daily use.
- Clinically Proven: 83% saw even tone in studies. My results matched the data.
- Versatile: Works for face, neck, chest. I used TNS everywhere.
- Long-Lasting: Small amounts suffice. My 1-ounce TNS lasted three months.
- Fragrance-Free Options: Even & Correct has no scent. My nose thanked me.
- Luxurious Feel: Creamy textures absorb well. My skin felt pampered. SkinMedica’s a powerhouse.
TNS Advanced+ Serum made my fine lines retreat in two weeks, leaving my skin plump and dewy—friends thought I’d cheated with fillers.
Even & Correct tackled my hyperpigmentation like a pro; my sunspots faded so much I ditched heavy makeup.
HA5 Rejuvenating Hydrator was a hydration hero, banishing my flaky cheeks with its five hyaluronic acid forms.
No irritation, even on my sensitive skin, which is rare for potent serums.
Clinical studies aren’t just fluff—83% of users saw brighter skin with Even & Correct, and my mirror agreed.
I slathered TNS on my neck and chest too, keeping everything smooth.
A little goes a long way; my $295 bottle lasted ages, softening the price shock.
Fragrance-free options like Even & Correct kept my allergies at bay.
The textures feel indulgent, like a mini-spa moment every morning.
If you want anti-aging and glow, SkinMedica’s your vibe.
Cons of SkinMedica:
- Pricey: $295 for TNS hurts. I saved up for months.
- Slow Results for Some: Even & Correct needs 8 weeks. I almost gave up.
- Pilling Risk: TNS pills under thick creams. My moisturizer clashed once.
- Scent in Some: TNS has a herbal smell. It bugged me initially.
- Limited Access: Only authorized retailers. I couldn’t grab it locally.
- Sunscreen Mandatory**: SPF 30+ is a must. I got burnt skipping it once.
- No Third-Party Testing: Lacks independent seals. I wanted more transparency.
- Pump Issues: TNS pump clogged. I cleaned it with tweezers.
- Not Pregnancy-Safe: Unclear for nursing moms. My sister avoided it.
SkinMedica’s wallet drain is real—$295 for TNS Advanced+ felt like buying a plane ticket.
Even & Correct’s results took eight weeks, testing my patience; I nearly bailed when week three showed nada.
TNS pilled under my heavy moisturizer once, leaving flakes I had to brush off.
Its herbal scent isn’t bad, but it annoyed my sensitive nose at first—Even & Correct’s scent-free vibe was better.
You can’t just pop into Target; it’s Dermstore or bust, which delayed my refills.
Sunscreen’s non-negotiable, and forgetting it once left my face redder than a lobster.
No third-party testing made me squint—show me a lab seal to prove it’s legit.
The TNS pump jammed twice, forcing me to play mechanic.
Pregnant or breastfeeding?
Safety’s iffy, so my sister skipped it during her first trimester.
These hiccups don’t kill the magic, but they’re worth weighing.
Pros of Alastin:

- Post-Procedure Star: Soothes after treatments. My microneedling redness faded overnight.
- Firms Skin: Restorative Complex boosts elasticity. My cheeks felt bouncier.
- Brightens Spots: A-Luminate fades hyperpigmentation. My jawline spots lightened.
- Lightweight: Silky, non-greasy feel. I layered it effortlessly.
- Clinically Backed: 60+ studies show results. My firmness improved.
- Gentle: No irritation. My sensitive skin stayed calm.
- Versatile: Works pre/post-procedure or daily. I used it everywhere.
- Long-Lasting: 1-ounce Complex lasts. Three months strong!
- Peptide Power: TriHex boosts collagen. My skin felt renewed.
Alastin’s a lifesaver, especially post-procedure.
After microneedling, Restorative Skin Complex calmed my angry skin by morning—my derm called it a must.
It firmed my cheeks, giving them a youthful bounce I hadn’t seen in years.
A-Luminate Brightening Serum tackled my jawline’s dark spots, fading them in a month with its niacinamide kick.
The lightweight textures are dreamy; they sink in without greasing up my face, perfect under sunscreen.
With over 60 peer-reviewed studies, it’s not just talk—my skin’s tighter, like the data promised.
No irritation, even on my fussy skin, which is huge.
I used it pre- and post-procedure, then kept it daily for all-over benefits.
A 1-ounce bottle of Complex lasted three months, easing the $199 sting.
TriHex Technology’s peptides are like a collagen factory, clearing old junk to make new, firm skin.
For recovery and elasticity, Alastin’s your go-to.
Cons of Alastin:
- Expensive: $199 for Complex isn’t cheap. I winced at checkout.
- Slower Brightening: A-Luminate takes time. My spots lingered longer.
- Dryness Risk: Needed extra moisturizer. Winter left me parched.
- Limited Retail: Derm offices or online only. I couldn’t shop locally.
- Sunscreen Must: SPF required. I got pink skipping it once.
- No Fragrance-Free Claim: Subtle scent. It bugged my nose slightly.
- Pump Clogs: Complex pump jammed. I fixed it with a paperclip.
- Not Pregnancy-Safe: Unclear for moms-to-be. My cousin passed.
- Less Acne Focus: Not for breakouts. I switched for pimples.
Alastin’s price hurts—$199 for Restorative Skin Complex made me gulp.
A-Luminate’s brightening was solid, but slower than SkinMedica; my dark spots took five weeks to fade, testing my resolve.
In winter, it left my skin thirsty, forcing me to slather on extra moisturizer.
You’re stuck buying from derms or Alastin.com—no quick Target runs for refills.
Sunscreen’s a must; I skipped it once and paid with a pink face.
The subtle scent isn’t fragrance-free, and it mildly annoyed my sensitive schnoz.
The Complex pump clogged twice, needing a quick fix.
Pregnancy safety’s murky—my cousin avoided it while expecting.
If acne’s your issue, Alastin’s not built for it; I swapped to a salicylic acid cleanser for breakouts.
These quirks don’t ruin it, but know what you’re getting.
Also Read: My Thoughts On Sun Coast Sciences Total Package Serum
Why I Choose Both (But You Might Not Need To)?

SkinMedica’s TNS Advanced+ and Even & Correct are my daily drivers for fine lines and sunspots—they’re gentle, fast, and luxe.
Alastin’s Restorative Skin Complex and A-Luminate are my go-to for post-procedure recovery and firmness, especially after derm treatments.
SkinMedica’s edge is hydration and speed; Alastin’s is elasticity and procedure prep.
If you’re on a budget, pick one based on your priority—anti-aging (SkinMedica) or recovery (Alastin).
Both are top-tier, but your skin type and goals decide the winner.
Key Features Breakdown
SkinMedica’s Standouts:
- TNS Advanced+ Serum: Growth factors and peptides reduce wrinkles in weeks. My skin looked six years younger, per studies.
- Even & Correct: 9% LTN Complex™ (niacinamide, tranexamic acid) fades melasma. My sunspots vanished.
- HA5 Hydrator: Five hyaluronic acids hydrate for eight hours. My dry skin drank it up.
Alastin’s Highlights
- Restorative Skin Complex: TriHex Technology® boosts collagen. My skin felt firmer post-microneedling.
- A-Luminate Brightening Serum: Niacinamide and peptides lighten spots. My jawline looked clearer.
- Regenerating Skin Nectar: Preps skin for procedures. My laser recovery was faster.
Also Read: My Thoughts On SkinMedica Lytera 2.0 Pigment Correcting Serum
Frequently Asked Questions (FAQs)
Yes, formulated with clinical-grade peptides and sold by derms.
SkinMedica may outperform for anti-aging; it depends on your needs.
Yes, widely endorsed for post-procedure and anti-aging benefits.
Yes, backed by clinical studies and sold through authorized retailers.
Final Thoughts
SkinMedica and Alastin both transformed my skin, but your choice hinges on your goals.
My journey shared pros, cons, and features to guide you.
SkinMedica’s your pick for fast anti-aging and brightening; Alastin’s ideal for firmness and recovery.
Grab the one that matches your skin’s dreams—you’ll glow in no time!