If you’re looking for a supplement that can naturally boost circulation, improve endurance, and support heart health, N1O1 Nitric Oxide Lozenges deserve serious consideration. Developed by Dr. Nathan S. Bryan, a leading expert in nitric oxide research, this formula is designed to rapidly increase nitric oxide levels—something that declines as we age. Since nitric oxide plays a major role in blood flow, energy levels, and cardiovascular function, keeping your levels optimized can be a game-changer.
I’ve personally used N1O1, and the results speak for themselves—better stamina, improved workout performance, and even lower blood pressure readings. Plus, this lozenge is backed by science, unlike many other nitric oxide supplements that rely on vague claims. If you want to enhance your circulation, endurance, and overall health, this is one supplement worth trying.
What Is N1O1 Nitric Oxide Lozenges and How Do They Work?

N1O1 Nitric Oxide Lozenges are a supplement designed to rapidly increase nitric oxide levels in the body, supporting circulation, cardiovascular health, and physical performance. Unlike many other nitric oxide boosters that rely on dietary nitrates or L-arginine, N1O1 takes a direct approach by using a scientifically formulated blend that immediately activates in the mouth. Developed by Dr. Nathan S. Bryan, a leading expert in nitric oxide research, these lozenges provide a fast and efficient way to enhance blood flow, oxygen delivery, and overall vascular health.
The way N1O1 works is simple yet highly effective. As the lozenge dissolves in the mouth, its proprietary blend of magnesium ascorbate and sodium nitrite interacts with the natural bacteria in the saliva to generate nitric oxide.
This bypasses the body’s traditional nitric oxide production pathways, which can become less efficient with age or certain health conditions. By stimulating nitric oxide release directly, these lozenges help dilate blood vessels, reduce blood pressure, and improve circulation, delivering more oxygen and nutrients to muscles and organs. This can lead to noticeable benefits like increased energy, better endurance, and improved workout performance.
Since nitric oxide plays a crucial role in vascular health, N1O1 can also support overall well-being by promoting heart health, cognitive function, and even sexual performance. Many users report feeling a difference within days of using the lozenges, making them a practical option for those looking for a quick and effective nitric oxide boost without relying on diet-based solutions.
How to Get the Most Out of N1O1 Nitric Oxide Lozenges?

To maximize the benefits of this supplement, follow these best practices:
- Take it correctly. Don’t swallow it whole. Let it dissolve in your mouth to activate nitric oxide production.
- Drink water before use. The instructions recommend drinking 2 to 4 ounces of water before taking the lozenge. This helps create the right environment for nitric oxide activation.
- Use it consistently. Many users report noticeable improvements after three to four weeks of daily use. Stay consistent for the best results.
- Avoid antibacterial mouthwash. Antibacterial mouthwashes can kill the beneficial bacteria in your mouth that help convert the ingredients into nitric oxide. Stick to fluoride-free toothpaste for better results.
- Pair it with a healthy lifestyle. While this supplement can support nitric oxide levels, its effects are even stronger when combined with regular exercise, a diet rich in leafy greens, and proper hydration.
Pros and Cons of N1O1 Nitric Oxide Lozenges

Pros:
- Fast-acting formula: Unlike many nitric oxide supplements that rely on slow digestion or conversion processes, N1O1 lozenges begin working immediately as they dissolve in the mouth. This leads to quicker and more noticeable effects, especially in circulation and endurance.
- Scientifically backed: Developed by Dr. Nathan S. Bryan, a leading nitric oxide researcher, this supplement is formulated based on solid scientific evidence. The ingredients are designed to optimize nitric oxide levels safely and effectively.
- Enhanced blood flow and circulation: By increasing nitric oxide production, N1O1 helps relax and expand blood vessels. This can lead to improved oxygen and nutrient delivery throughout the body, supporting better cardiovascular health and muscle performance.
- Supports healthy blood pressure: Regular use of N1O1 has been linked to improved blood pressure levels. Many users have reported lower readings after consistent use, making it an appealing option for those looking for a natural way to manage their cardiovascular health.
- Boosts physical performance and endurance: Because nitric oxide plays a key role in oxygen delivery and muscle function, many athletes and fitness enthusiasts experience greater stamina, faster recovery, and improved overall performance when using N1O1.
- No L-arginine dependency: Unlike many other nitric oxide boosters that rely on L-arginine, which becomes less effective with age, N1O1 works independently of this pathway. This makes it a better option for people over 40 or those who do not respond well to L-arginine-based supplements.
- Convenient and easy to use: Unlike powders or capsules that require mixing or swallowing, N1O1 comes in a dissolvable lozenge form, making it a simple and mess-free addition to your routine.
- Does not require dietary nitrates: Some nitric oxide supplements rely on foods like beets or leafy greens for their nitrate content, which can be inconsistent in effectiveness. N1O1 provides a direct nitric oxide boost without the need for dietary modifications.
Cons:
- Price: Compared to other nitric oxide supplements, N1O1 is on the more expensive side. While the science and effectiveness justify the cost, it may not be the best choice for those on a tight budget.
- Taste and texture: Some users find the taste of the lozenges less than pleasant, describing them as chalky or similar to antacid tablets. Since they need to dissolve in the mouth, there is no way to bypass the flavor.
- Requires consistent use: While some effects may be felt quickly, long-term benefits such as improved cardiovascular health and blood pressure regulation require daily use. Missing doses may reduce the supplement’s overall effectiveness.
- Not available in all regions: Some users have reported difficulty finding N1O1 outside of the U.S. and have requested international availability, particularly in the UK and Europe.
- May not work the same for everyone: While N1O1 is designed to be effective for most people, individual results can vary based on factors like diet, health conditions, and existing nitric oxide levels. Some users may experience more dramatic improvements than others.
- Can be impacted by oral hygiene habits: Since nitric oxide production begins in the mouth, using antibacterial mouthwash or fluoride-based toothpaste can reduce its effectiveness. Users may need to adjust their oral care routine to get the best results.
Also Read: My Thoughts On Nugenix Nitric Oxide Booster
N1O1 Nitric Oxide Lozenges Vs. Other Brands
- N1O1 Vs. Berkeley Life Nitric Oxide Support
Berkeley Life relies on plant-based nitrates to boost nitric oxide levels, which can be effective but depends on your body’s ability to convert nitrates into nitric oxide. This process varies from person to person and may not be as reliable. N1O1, on the other hand, works directly in the mouth by activating nitric oxide production instantly. This makes it a more immediate and consistent option for those looking to optimize circulation and endurance without relying on digestion-based conversion.
- N1O1 Vs. Humann SuperBeets
SuperBeets is a popular nitric oxide booster that uses beetroot powder as its main ingredient. While beets are a natural source of nitrates, the conversion process depends on factors like gut health and oral bacteria, making the results inconsistent. N1O1 bypasses this issue by using a scientifically formulated blend that generates nitric oxide directly in the mouth. This means faster absorption, more predictable results, and a more effective nitric oxide boost compared to beet-based supplements.
- N1O1 Vs. L-Arginine-Based Supplements
Many nitric oxide supplements rely on L-arginine, an amino acid that helps the body produce nitric oxide. However, research shows that as we age, our ability to convert L-arginine into nitric oxide declines, making these supplements less effective—especially for people over 40. N1O1 skips the inefficient L-arginine pathway and works through a more direct mechanism, ensuring that nitric oxide levels increase regardless of age or metabolic efficiency.
- N1O1 Vs. Neo40
Neo40 is another lozenge-based nitric oxide supplement, but it takes a slightly different approach by incorporating botanicals and vitamins. While Neo40 is a solid option, many users report that its effects take longer to kick in compared to N1O1. Because N1O1 is designed to dissolve in the mouth and produce nitric oxide instantly, it delivers a more immediate boost, making it the better choice for those who want fast-acting results.
- N1O1 Vs. Generic Nitric Oxide Boosters
There are countless generic nitric oxide supplements on the market, but most do not disclose their actual nitric oxide production levels, leaving users guessing about their effectiveness. Many of these formulas rely on outdated methods like L-arginine or unverified nitrate sources. N1O1 stands out because it was developed by a leading nitric oxide researcher and follows a science-backed approach that ensures real, measurable increases in nitric oxide levels. If you want a supplement with proven results rather than marketing hype, N1O1 is the superior choice.
lso Read: My Experience With Nutricost Nitric Oxide Booster
Frequently Asked Questions (FAQs)
Yes, nitric oxide lozenges like N1O1 are designed to deliver a quick and effective boost to nitric oxide levels. Unlike L-arginine-based supplements that depend on complex metabolic pathways, N1O1 works directly in the mouth to generate nitric oxide on the spot. Many users report noticeable improvements in endurance, circulation, and overall energy levels.
N1O1 supports cardiovascular health, improves circulation, enhances athletic performance, and helps regulate blood pressure. It also promotes better oxygen delivery to muscles and organs, which can lead to increased stamina and overall well-being. Many users find it especially beneficial for exercise performance and recovery.
Yes, it is generally safe to take nitric oxide supplements daily as long as they are used as directed. However, it’s always a good idea to consult with a healthcare provider if you have any underlying health conditions or are taking medications that could interact with nitric oxide boosters.
People with low blood pressure, certain heart conditions, or those taking medications for blood pressure regulation should consult a doctor before taking nitric oxide supplements. Additionally, individuals with a history of kidney disease or those on blood-thinning medications should be cautious when using nitric oxide boosters.
Final Thoughts
After trying N1O1 for myself, I can confidently say this product delivers on its promises. My endurance has improved, my workouts feel stronger, and even my blood pressure readings have seen a positive shift. While the taste isn’t the best, the benefits far outweigh that minor drawback. Unlike many nitric oxide supplements that rely on outdated or inefficient pathways, N1O1 takes a science-backed approach that works directly in the mouth for fast results.
If you’re serious about improving circulation, boosting stamina, and supporting heart health, N1O1 Nitric Oxide Lozenges are worth the investment.